1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 18507510, compound

HRID 1356199Notes

Reaction equation

HRID 1356199 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][C:10]([CH:13]([F:15])[F:14])=[CH:11][CH:12]=2)[C:5]([C:16]#[N:17])=[C:4]([S:18]([CH3:20])=O)[N:3]=1.SC[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][C:10]([CH:13]([F:15])[F:14])=[CH:11][CH:12]=2)[C:5]([C:16]#[N:17])=[C:4]([S:18][CH2:20][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[N:3]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 1509632-PyridineethanethiolHCID 18507503HCID 18507503, compound

Product 1

HCID 18507510HCID 18507510, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-(5-difluoromethyl-furan-2-yl)-6-methanesulfinyl-pyrimidine-5-carbonitrile, 2-mercaptoethylpyridine and DBU in DME. ES-MS m/e (%): 374 (M+H+, 100).

Sources & evidence

ORD record
ord-70721cf0e34245f59eee9e11595d400c
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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