1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 69782098, compound

HRID 1356200Notes

Reaction equation

HRID 1356200 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.[OH:18][CH2:19][C:20]1[N:25]=[CH:24][C:23]([O:26][C:27](=[O:31])[N:28]([CH3:30])[CH3:29])=[CH:22][CH:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([O:18][CH2:19][C:20]2[N:25]=[CH:24][C:23]([O:26][C:27](=[O:31])[N:28]([CH3:29])[CH3:30])=[CH:22][CH:21]=2)[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrileHCID 69491567HCID 69491567, compound

Product 1

HCID 69782098HCID 69782098, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, dimethyl-carbamic acid 6-hydroxymethyl-pyridin-3-yl ester and DBU in DME. ES-MS m/e (%): 403 (M+Na+, 45), 381 (M+H+, 100).

Sources & evidence

ORD record
ord-a378b7d00a7042738db8f22bce40c361
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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