HCID 22396816, compound → HCID 69893822, compound

HRID 1356374Notes

Reaction equation

HRID 1356374 reaction equation
Cl.Cl.[Cl:3]C1C=CC(C2C3C4CCNCCC4NC=3C=CC=2)=CC=1.Cl.Cl.[Cl:26][C:27]1[CH:28]=[C:29]([C:33]2[C:34]3[C:35]4[CH2:46][CH2:45][NH:44][CH2:43][CH2:42][C:36]=4[NH:37][C:38]=3[CH:39]=[CH:40][CH:41]=2)[CH:30]=[CH:31][CH:32]=1>>[ClH:3].[ClH:26].[Cl:26][C:27]1[CH:28]=[C:29]([C:33]2[C:34]3[C@@H:35]4[CH2:46][CH2:45][NH:44][CH2:43][CH2:42][C@@H:36]4[NH:37][C:38]=3[CH:39]=[CH:40][CH:41]=2)[CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 22396816HCID 22396816, compoundHCID 22609212HCID 22609212, compound

Product 1

HCID 69893822HCID 69893822, compound

Procedure

Following the procedure for the preparation of 10-(4-chlorophenyl)-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole dihydrochloride, making non-critical variations, starting from 10-(3-chlorophenyl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole dihydrochloride the title compound was prepared: 1H NMR (DMSO-d6) δ 1.35, 1.55, 2.10, 2.71, 3.05, 3.28, 3.97, 4.20, 6.65, 7.12, 7.4-7.5, 8.8. HRMS (FAB) calcd for C18H21ClN12 (MH+) 299.1315, found 299.1306.

Sources & evidence

ORD record
ord-6e348b0a0af84bc686977ee71abb2a67
Source dataset
uspto-grants-2003_07
Patent number
US06586421B2

Reaction notes

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