N-Methylethylenediamine → 2,2,2-trifluoro-N-[2-(methylamino)ethyl]acetamide

HRID 1356450Notes

Reaction equation

HRID 1356450 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]([O:5]CC)=O.[CH3:10][NH:11][CH2:12][CH2:13][NH2:14]>C(OCC)C>[F:9][C:2]([F:1])([F:8])[C:3]([NH:14][CH2:13][CH2:12][NH:11][CH3:10])=[O:5]

Participants

4

Reactant 2

HCID 8014N-MethylethylenediamineHCID 9794Ethyl trifluoroacetate

Product 1

HCID 107022842,2,2-trifluoro-N-[2-(methylamino)ethyl]acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of ethyl trifluoroacetate (10 ml) in diethyl ether (20 ml) in an ice bath was added dropwise N-methylethylenediamine (7.4ml) for one hr. After addition, the reaction mixture was warmed to room temperature and stirred for 2 hr. Removal of ethyl ether from the reaction mixture gave the titled compound (14 g).

Workup

  1. additionAfter addition
  2. customRemoval of ethyl ether from the reaction mixture

Sources & evidence

ORD record
ord-0c90826f741147f39366c3d0d7efbf58
Source dataset
uspto-grants-2003_07
Patent number
US06586475B1

Reaction notes

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