N-Methylethylenediamine → 2,2,2-trifluoro-N-[2-(methylamino)ethyl]acetamide

Participants

Reaction Steps

To a solution of ethyl trifluoroacetate (10 ml) in diethyl ether (20 ml) in an ice bath was added dropwise N-methylethylenediamine (7.4ml) for one hr. After addition, the reaction mixture was warmed to room temperature and stirred for 2 hr. Removal of ethyl ether from the reaction mixture gave the titled compound (14 g).

Provenance & Evidence