反应详情

To a solution of tert-butyl(methyl)[2-[(2,2,2-trifluoroacetyl)amino]ethyl]carbamate (1 g) in methanol (10 ml) in an ice bath was added aqueous 10% potassium carbonate (5 ml). After addition, the reaction mixture was warmed to room temperature and stirring was continued for additional 20 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The insoluble material was removed by filtration and the filtrate was concentrated to obtain the titled compound (451 mg).

1. additionAfter addition
2. concentrationThe reaction mixture was concentrated
3. dissolutionthe residue was dissolved in ethyl acetate
4. customThe insoluble material was removed by filtration
5. concentrationthe filtrate was concentrated