HCID 18508351, compound → HCID 18508359, compound

HRID 1356456Notes

Reaction equation

HRID 1356456 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][N:5]([CH3:26])[C:6](=[O:25])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14]C(=O)OCC2C=CC=CC=2)=[CH:10][CH:9]=1>C(O)C.[Pd]>[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][C:6]([N:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH3:27])[CH3:26])=[O:25])=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 18508351HCID 18508351, compound

Product 1

HCID 18508359HCID 18508359, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl 4-(2-((2-(dimethylamino)ethyl)(methyl)amino)-2-oxoethyl)phenylcarbamate (0.7 g) in ethanol (10 ml) was added 10% Pd-C (0.2 g). The reaction mixture was hydrogenated under atmospheric pressure at room temperature for one hr. The catalyst was removed by filtration and the filtrate was concentrated to obtain the titled compound (0.43 g).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-af0701dfd6184750b9f027b191a68f09
Source dataset
uspto-grants-2003_07
Patent number
US06586475B1

Reaction notes

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