反应详情

A suspension of methyl 4-(4-biphenylylmethoxy)phenylacetate (1.00 g), N,N-dimethylethylenediamine (0.80 g), and imidazole (205 mg) in methanol (2.0 ml) was heated under reflux under nitrogen for 30 min and cooled until the temperature of the reaction mixture reached to 60±2° C. Methanol (4.0 ml) was added to the reaction mixture, which was heated under reflux for additional one hr and cooled to room temperature. The precipitate was collected by filtration and washed with methanol (2.0 ml) to obtain the titled compound (1.03 g).

1. temperaturewas heated
2. temperatureunder reflux under nitrogen for 30 min
3. temperaturecooled until the temperature of the reaction mixture
4. customreached to 60±2° C
5. temperaturewas heated
6. temperatureunder reflux for additional one hr
7. filtrationThe precipitate was collected by filtration
8. washwashed with methanol (2.0 ml)