Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylcyclohexane | HCID 7962 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 54201432 | HCID 54201432 | — |
Reaction Steps
8 l of methylcyclohexane are initially charged and 3000 g of 4-fluorobenzaldehyde, 5000 g of 4-trifluoromethylacetophenone and 150 ml of conc. hydrochloric acid are added. The mixture is distilled azeotropically for approximately 8 hours until no more water separates off. After cooling to 10 to 15° C., the precipitated solid is filtered off with suction and washed with cold methylcyclohexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06586613B1 |
|---|
| Source dataset | uspto-grants-2003_07 |
|---|
| ORD ID | ord-878fe9700f3f47a2abf7f4b6da988f7b |
|---|
| Source note | uspto-grants-2003_07 |
|---|
