Methylcyclohexane → HCID 54201432, compound

HRID 1356566Notes

Reaction equation

HRID 1356566 reaction equation
CC1CCCCC1.[F:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.[CH3:17][C:18]([C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=1)=[O:19]>Cl>[F:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[CH:17][C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=2)=[O:19])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 7962MethylcyclohexaneHCID 680234-FluorobenzaldehydeHCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-one

Product 1

HCID 54201432HCID 54201432, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
12.5 °C

Procedure

8 l of methylcyclohexane are initially charged and 3000 g of 4-fluorobenzaldehyde, 5000 g of 4-trifluoromethylacetophenone and 150 ml of conc. hydrochloric acid are added. The mixture is distilled azeotropically for approximately 8 hours until no more water separates off. After cooling to 10 to 15° C., the precipitated solid is filtered off with suction and washed with cold methylcyclohexane.

Workup

  1. distillationThe mixture is distilled azeotropically for approximately 8 hours until no more water
  2. filtrationthe precipitated solid is filtered off with suction
  3. washwashed with cold methylcyclohexane

Sources & evidence

ORD record
ord-878fe9700f3f47a2abf7f4b6da988f7b
Source dataset
uspto-grants-2003_07
Patent number
US06586613B1

Reaction notes

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