反应详情

温度

40 °C

To a 2 l of three-necked flask equipped with reflux condenser, thermometer and mechanical stirrer were charged (S)-3-hydroxy-γ-butyrolactone (102 g) and 30% of hydrobromic acid in acetic acid (675 g, 2.5 eq.). The mixture was stirred at 40° C. for 3 hours. After cooling the reaction mixture, methylene chloride (1000 ml) was added to it. The reaction mixture was washed with aqueous solution of sodium acetate. The organic layer was separated, dried over magnesium sulfate, and concentrated to afford (S)-3-acetoxy-4-bromobutyric acid (213 g, 95%).

1. customTo a 2 l of three-necked flask equipped
2. temperaturewith reflux condenser
3. additionwas added to it
4. washThe reaction mixture was washed with aqueous solution of sodium acetate
5. customThe organic layer was separated
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated