反应详情

温度

20 °C

Racemic cis-1-amino-2-indanol (66.6 g, water wet, content 81.1%) and 65 g of (R,R)-tartaric acid in 360 ml of methanol with 20 ml of water were brought to reflux. Stirring of the mixture was continued for one hour at reflux and then it was cooled down again to 20° C. The solid was isolated by filtration and washed twice with 120 ml of methanol. After drying, 54.3 g of (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate were obtained with an e.e. of 96.7%.

1. temperatureto reflux
2. temperatureat reflux
3. customThe solid was isolated by filtration
4. washwashed twice with 120 ml of methanol
5. customAfter drying