反应详情

温度

70 °C

To a solution of 4-nitroisophthalamide (6.0 g (28.7 mmol) in ethanol (150.0 ml), stannous chloride (20.02 g (86.1 mmol) was added and the mixture was stirred at 70° C. overnight. After cooling, the reaction mixture was neutralized with a saturated aqueous sodium bicarbonate solution, and insolubles formed were removed by filtration. The filtrate was extracted with ethyl acetate and the extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 2.59 g (50%) of 4-aminoisophthalamide as pale yellow crystals.

1. temperatureAfter cooling
2. customformed
3. customwere removed by filtration
4. extractionThe filtrate was extracted with ethyl acetate
5. dry with materialthe extract was dried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure