反应详情

To a solution of 4-Aminophenyl thiocyanate (10.0 g (66.6 mmol)) in pyridine (70 ml), p-toluenesulfonyl chloride (12.7 g (66.6 mmol)) was added with stirring at room temperature, and the mixture was stirred at room temperature for 16 hours. Then, water was added to the reaction mixture and the resulting mixture was extracted with ethyl acetate. The extract was washed with dilute hydrochloric acid and a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give 19.4 g (98%) of 4′-thiocyano-p-toluenesulfonanilide as pale yellow crystals.

1. stirringthe mixture was stirred at room temperature for 16 hours
2. extractionthe resulting mixture was extracted with ethyl acetate
3. washThe extract was washed with dilute hydrochloric acid
4. dry with materiala saturated aqueous solution of sodium chloride, dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure