Sodium Carbonate → HCID 18509482, compound

HRID 1356816Notes

Reaction equation

[CH:1]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:22][CH:23]=[CH:24][C:25]#[C:26][C:27]([CH3:30])([CH3:29])[CH3:28]>>[CH3:28][C:27]([CH3:30])([CH3:29])[C:26]#[C:25]/[CH:24]=[CH:23]/[CH2:22][N:4]([CH2:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1)[CH:1]([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 10340Sodium Carbonate

HCID 18509452HCID 18509452, compound

HCID 454895941-Bromo-6,6-dimethylhept-2-en-4-yne

Product 1

HCID 18509482HCID 18509482, compoundYield 61.8%

Procedure

The procedure described in Example 13 was repeated, except that 3′-(N-isopropylaminomethyl)acetophenone (1.66 g; 8.7 mmol), sodium carbonate (925 mg; 8.7 mmol), and 1-bromo-6,6-dimethyl-2-hepten-4-yne (1.74 g; 8.7 mmol) were used, to thereby yield 1.67 g of the target compound (yield: 61.8%).

Sources & evidence

ORD record: ord-b280d3dc67704f01a954a4b48bd5fa24
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06586633B1

Reaction notes

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