trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-ethyl-(3-isopropenylbenzyl)amine → trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-ethyl-(3-isopropenylbenzyl)amine Hydrochloride
Reaction equation
[CH3:1][C:2]([CH3:22])([CH3:21])[C:3]#[C:4]/[CH:5]=[CH:6]/[CH2:7][N:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([CH3:20])=[CH2:19])[CH:13]=1)[CH2:9][CH3:10].[ClH:23].C(OCC)(=O)C>>[ClH:23].[CH3:21][C:2]([CH3:1])([CH3:22])[C:3]#[C:4]/[CH:5]=[CH:6]/[CH2:7][N:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([CH3:20])=[CH2:19])[CH:13]=1)[CH2:9][CH3:10]Participants
3
Procedure
The procedure described in Example 12 was repeated, except that Compound 44 (950 mg; 3.2 mmol) and 4N hydrochloric acid—ethyl acetate solution (0.85 ml; 3.4 mmol) were used, to thereby yield 710 mg of the target compound (yield: 66.5%).
Sources & evidence
- ORD record
- ord-a05cfe2a5c1b4f19ab8d1dfc945ef06e
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06586633B1
Reaction notes
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