Hydrochloric Acid → HCID 54529230, compound

HRID 1356857Notes

Reaction equation

HRID 1356857 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]1[CH2:32][CH2:31][CH2:30][C@H:15]1[C:16]([NH:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])(=[O:13])=[O:12])=[O:4].[OH-].[Na+].Cl>O1CCOCC1>[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]1[CH2:32][CH2:31][CH2:30][C@H:15]1[C:16]([NH:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:17])(=[O:13])=[O:12])([OH:4])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53805764HCID 53805764, compound

Product 1

HCID 54529230HCID 54529230, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product of Example 18 (56) (1.8 mmoles) was mixed with dioxane (25 mL) and 1N NaOH (1.8 mmoles) and the reaction was stirred at room temperature for 16 hours. 1N HCl (1.8 mmoles) was added and the water and dioxane were removed under reduced pressure. The product was extracted with 0.2 N NaOH (50 mL) and EtOAc (2×50 mL) and the recovered organic layer was dried over MgSO4, filtered, and concentrated to yield a colorless oil.

Workup

  1. customthe water and dioxane were removed under reduced pressure
  2. extractionThe product was extracted with 0.2 N NaOH (50 mL) and EtOAc (2×50 mL)
  3. dry with materialthe recovered organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto yield a colorless oil

Sources & evidence

ORD record
ord-6544975e11d54222ada3281c20910e36
Source dataset
uspto-grants-2003_07
Patent number
US06586602B2

Reaction notes

Loading…