O-Methylhydroxylamine hydrochloride → HCID 54416592, compound

HRID 1356867Notes

Reaction equation

HRID 1356867 reaction equation
[C:1]1([CH3:29])[CH:6]=[CH:5][C:4]([S:7]([N:10]2[CH2:28][CH2:27][CH2:26][C@H:11]2[C:12]([NH:14][C@H:15]([C:23]([OH:25])=O)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:13])(=[O:9])=[O:8])=[CH:3][CH:2]=1.Cl.[CH3:31][O:32][NH2:33]>>[CH3:31][O:32][NH:33][C:23](=[O:25])[C@H:15]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[NH:14][C:12](=[O:13])[C@@H:11]1[CH2:26][CH2:27][CH2:28][N:10]1[S:7]([C:4]1[CH:3]=[CH:2][C:1]([CH3:29])=[CH:6][CH:5]=1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 9931728HCID 9931728, compound

Product 1

HCID 54416592HCID 54416592, compound

Procedure

N-(Toluene-4-sulfonyl)-L-prolyl-L-phenylalanine was coupled to O-methylhydroxylamine hydrochloride using the mixed anhydride procedure (as described in Greenstein, J. P. and Milton Wenitz, “Chemistry of the Amino Acids,” volume 2, pp. 978-979, Robert E. Krieger Publishing Co., Malabar, Fla. (1961)) to give the title compound as an oil.

Sources & evidence

ORD record
ord-c9dc4af1676443d2921addd691fab2a1
Source dataset
uspto-grants-2003_07
Patent number
US06586602B2

Reaction notes

Loading…