HCID 69991543, compound → HCID 86759058, compound

HRID 1356991Notes

Reaction equation

HRID 1356991 reaction equation
[CH3:1][CH:2]1[N:7]([C:8]2[CH:9]=[C:10]([N+:14]([O-])=O)[CH:11]=[CH:12][CH:13]=2)[CH:6]([CH3:17])[CH2:5][O:4][CH2:3]1>C(O)C.[Pd]>[CH3:1][CH:2]1[N:7]([C:8]2[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=2)[NH2:14])[CH:6]([CH3:17])[CH2:5][O:4][CH2:3]1

Participants

4

Reactant 1

HCID 69991543HCID 69991543, compound

Product 1

HCID 86759058HCID 86759058, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Meta-(3,5dimethylmorphohno) nitrobenzene (1a) (2 g, 8.5 mmol) is hydrogenated in ethanol (50 ml), over 10%Pd on carbon (200 mg) for 1.5 hours. The catalyst is removed by filtration and the solvent removed evaporation to yield an oil. The enantiomers can be separated by silica column chromatography. ES+ (M+1) 207.36.

Workup

  1. customfor 1.5 hours
  2. customThe catalyst is removed by filtration
  3. customthe solvent removed
  4. customevaporation
  5. customto yield an oil
  6. customThe enantiomers can be separated by silica column chromatography

Sources & evidence

ORD record
ord-bef59b385d6d40c6b03f6a27d75d864b
Source dataset
uspto-grants-2003_07
Patent number
US06589950B1

Reaction notes

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