Morpholine → 4-(3-Nitrophenyl)morpholine

HRID 1356992Notes

Reaction equation

HRID 1356992 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[CH:3]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[O:14]1[CH2:15][CH2:16][N:11]([C:2]2[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 98231-Fluoro-3-nitrobenzene

Product 1

HCID 12532734-(3-Nitrophenyl)morpholine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Using 1-fluoro-3-nitrobenzene (10 g, 0.07M) and morpholine (33.5 g, 0.38M) in DMSO (116 ml) is prepared using the method described by Brown G. R. et al., Tet. Lett. 40 (1999) 1219-1222. Filtration of the precipitated product yields the product; mp 113.8-115.5° C.

Workup

  1. customis prepared
  2. filtrationFiltration of the precipitated product
  3. customyields the product

Sources & evidence

ORD record
ord-120c91f5d49349e2ba181f3c8ccb7679
Source dataset
uspto-grants-2003_07
Patent number
US06589950B1

Reaction notes

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