HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Benzyl cyclopropyl(methyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzyl cyclopropylcarbamate | HCID 13141013 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzyl cyclopropyl(methyl)carbamate | HCID 13141014 | — |
Reaction Steps
The synthesis of N-carbobenzyloxy cyclopropylamine is carried out according to the method outlined in J. Heterocycl. Chem (1983), 1035, using N-carbobenzyloxy cyclopropylamine (14a)(10.5 g, 0.055M) in DMF (80 ml), sodium hydride(1.4 g) and methyl iodide (4 ml). The product is purified by vacuum distillation. Bp 86-92° C., 0.02 Torr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06589950B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-76dc4b9e562644539193777b1ce60f2b |
| Source note | uspto-grants-2003_07 |