Methyl iodide → HCID 13141014, compound

HRID 1356998Notes

Reaction equation

HRID 1356998 reaction equation
[C:1]([NH:11][CH:12]1[CH2:14][CH2:13]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[H-].[Na+].[CH3:17]I>CN(C=O)C>[CH3:17][N:11]([CH:12]1[CH2:14][CH2:13]1)[C:1]([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 13141013Benzyl cyclopropylcarbamate2×

Product 1

HCID 13141014HCID 13141014, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The synthesis of N-carbobenzyloxy cyclopropylamine is carried out according to the method outlined in J. Heterocycl. Chem (1983), 1035, using N-carbobenzyloxy cyclopropylamine (14a)(10.5 g, 0.055M) in DMF (80 ml), sodium hydride(1.4 g) and methyl iodide (4 ml). The product is purified by vacuum distillation. Bp 86-92° C., 0.02 Torr.

Workup

  1. distillationThe product is purified by vacuum distillation

Sources & evidence

ORD record
ord-76dc4b9e562644539193777b1ce60f2b
Source dataset
uspto-grants-2003_07
Patent number
US06589950B1

Reaction notes

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