Malonic Acid → 3-amino-3-(3-methoxyphenyl)propanoic acid

HRID 1357085Notes

Reaction equation

HRID 1357085 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.[C:11]([O-:14])(=[O:13])[CH3:12].[NH4+:15].C(O)(=O)CC(O)=O>>[NH2:15][CH:6]([C:5]1[CH:8]=[CH:9][CH:10]=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:12][C:11]([OH:14])=[O:13]

Participants

4

Reactant 3

HCID 867Malonic AcidHCID 115693-MethoxybenzaldehydeHCID 517165Ammonium Acetate

Product 1

HCID 27642943-amino-3-(3-methoxyphenyl)propanoic acid

Procedure

Corresponding to Example 1a, 200 g of 3-methoxybenzaldehyde were reacted with ammonium acetate and malonic acid. A white solid was obtained (yield: 135.5 g).

Workup

  1. customA white solid was obtained (yield: 135.5 g)

Sources & evidence

ORD record
ord-49ae7957c7664098a88baf7219df9865
Source dataset
uspto-grants-2003_07
Patent number
US06589972B2

Reaction notes

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