反应详情

To a solution of 3-(1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-N-methylmaleimide (60 mg, 0.17 mmol) in DMF (1 mL) was added a small amount of 10% palladium-carbon, and the whole was stirred at room temperature for 1 day under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane =2:1) to obtain 4-(1H-indol-3-yl)-3-(1-methyl-1H-indol-3-yl)-1-methyl-2,5-dioxopyrrolidine (60 mg, 99.6%) as pale red solids. 1H-NMR(CDCl3): δ 3.27(s, 3H), 3.34(s, 3H), 4.76(s, 2H) 6.58-7.32(m, 10H), 7.72(br s, 1H).

1. customThe palladium-carbon was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane =2:1)