Pyrazole → HCID 10224403, compound

HRID 1357140Notes

Reaction equation

HRID 1357140 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[N:6]1[S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18].[NH:27]1[CH:31]=[CH:30][CH:29]=[N:28]1>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH:7]2[N:6]([S:17]([C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[CH:5]([CH2:4][CH2:3][CH2:2][N:27]3[CH:31]=[CH:30][CH:29]=[N:28]3)[CH2:9][CH2:8]2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 22250442HCID 22250442, compound

Product 1

HCID 10224403HCID 10224403, compound

Procedure

The title compound, colorless oil, MS: m/e=428.5 (M+H+), was prepared in accordance with the general method of example 82b from (2RS,5RS)-2-(3-chloro-propyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 1H-pyrazole.

Sources & evidence

ORD record
ord-195d157332c644caa11f8d3d957705e3
Source dataset
uspto-grants-2003_07
Patent number
US06589978B2

Reaction notes

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