Pyrazole → (2RS,5SR)-1-{2-[5-(4-Fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-ethyl}-1H-pyrazole

HRID 1357147Notes

Reaction equation

HRID 1357147 reaction equation
Cl[CH2:2][CH2:3][CH:4]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[N:5]1[S:16]([C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=1)(=[O:18])=[O:17].[NH:26]1[CH:30]=[CH:29][CH:28]=[N:27]1>>[F:15][C:12]1[CH:11]=[CH:10][C:9]([CH:6]2[N:5]([S:16]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:4]([CH2:3][CH2:2][N:26]3[CH:30]=[CH:29][CH:28]=[N:27]3)[CH2:8][CH2:7]2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 22250484(2RS,5RS)-2-(2-chloro-ethyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

Product 1

HCID 22250492(2RS,5SR)-1-{2-[5-(4-Fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-ethyl}-1H-pyrazole

Procedure

The title compound, white solid, m.p.=121° C. and MS: m/e=414.2 (M+H+), was prepared in accordance with the general method of example 82b from (2RS,5RS)-2-(2-chloro-ethyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 1H-pyrazole.

Sources & evidence

ORD record
ord-0946ea116be44be8a307a3521999e0ad
Source dataset
uspto-grants-2003_07
Patent number
US06589978B2

Reaction notes

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