Methyl iodide → Methyl 2-methyl-3-oxopentanoate

HRID 1357179Notes

Reaction equation

HRID 1357179 reaction equation
CI.[C:3]([O-])([O-])=O.[K+].[K+].[C:9]([CH2:13][C:14]([O:16][CH3:17])=[O:15])(=[O:12])[CH2:10][CH3:11]>CC(C)=O>[CH3:3][CH:13]([C:9](=[O:12])[CH2:10][CH3:11])[C:14]([O:16][CH3:17])=[O:15]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 121699Methyl 3-oxovalerate

Product 1

HCID 545860Methyl 2-methyl-3-oxopentanoate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Methyl iodide (57 ml) and K2CO3 (127 g) were added to a solution of methyl propionylacetate (100 g) in acetone (800 ml) while cooling on ice. The reaction solution was stirred for 96 hours at room temperature and celite filtered, and then the mother liquor was slowly concentrated under reduced pressure and distilled under reduced pressure to obtain methyl 2-methyl-3-oxopentanoate.

Workup

  1. temperaturewhile cooling on ice
  2. filtrationcelite filtered
  3. concentrationthe mother liquor was slowly concentrated under reduced pressure
  4. distillationdistilled under reduced pressure

Sources & evidence

ORD record
ord-d36bac8f934f4ab9af43a8e39619584d
Source dataset
uspto-grants-2003_07
Patent number
US06589984B1

Reaction notes

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