Acetic Anhydride → HCID 86589721, compound

HRID 1357205Notes

Reaction equation

HRID 1357205 reaction equation
CC(OC(C)=O)=O.NC1C=CC2OC([C:17]3[O:22][C:21](=[O:23])[C:20]([CH3:24])=[C:19]([O:25][CH2:26][O:27][CH3:28])[C:18]=3[CH3:29])=CC=2C=1.[NH4+].[Cl-]>N1C=CC=CC=1>[CH3:24][C:20]1[C:21](=[O:23])[O:22][CH:17]=[C:18]([CH3:29])[C:19]=1[O:25][CH2:26][O:27][CH3:28]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 25517Ammonium ChlorideHCID 18505628HCID 18505628, compound

Product 1

HCID 86589721HCID 86589721, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Pyridine (400 μl) and Ac2O (15 μl) were added to 6-(5-aminobenzofuran-2-yl)-3,5-dimethyl-4-methoxymethoxy-2H-pyran-2-one (45 mg), and after stirring the mixture at room temperature for 6 hours, an NH4Cl aqueous solution was added and extraction was performed with CH2Cl2. The organic layer was dried, filtered and concentrated, and the residue was purified by silica gel thin-layer chromatography (CH2Cl2) to obtain 6-(5-acetylamino)benzofuran-2-yl)-3,5-dimethyl-4-methoxymethoxy-2H-pyran-2-one.

Workup

  1. extractionextraction
  2. customThe organic layer was dried
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customthe residue was purified by silica gel thin-layer chromatography (CH2Cl2)

Sources & evidence

ORD record
ord-e290f4989e9b4573a3ea26a8a46dff98
Source dataset
uspto-grants-2003_07
Patent number
US06589984B1

Reaction notes

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