Methyl iodide → HCID 10138421, compound

HRID 1357484Notes

Reaction equation

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.CI>>[CH:8]1[C:9]2[C:4](=[N:1][C:22]3[C:17]([C:16]=2[NH:1][C:4]2[CH:9]=[CH:8][C:7]([N:10]4[CH2:15][CH2:14][N:13]([CH2:16][C:17]5[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=5)[CH2:12][CH2:11]4)=[CH:6][CH:5]=2)=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 7498Benzyl Bromide

HCID 804471-(4-Nitrophenyl)piperazine

Product 1

HCID 10138421HCID 10138421, compoundYield 2%

Procedure

Following the procedure outlined in Step 1 of Example 1, but substituting 9-[4-(piperazin-1-yl)phenyl]aminoacridine (Example 16) for N-(4-nitrophenyl)piperazine, and benzyl bromide for methyl iodide, afforded the title compound (15%, overall yield 2%)

Sources & evidence

ORD record: ord-68e2c2fbeaea453a9d7b94344e0754ae
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06593324B2

Reaction notes

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