HCID 91616889, compound → HCID 90829811, compound

HRID 1357506Notes

Reaction equation

HRID 1357506 reaction equation
[C:1]([NH:4][C@@H:5]1[C@H:10]([OH:11])[CH2:9][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C@H:6]1[O:16][CH:17]([CH3:19])[CH3:18])(=[O:3])[CH3:2]>ClCCl>[C:1]([NH:4][C@@H:5]1[C:10](=[O:11])[CH2:9][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C@H:6]1[O:16][CH:17]([CH3:19])[CH3:18])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 91616889HCID 91616889, compound

Product 1

HCID 90829811HCID 90829811, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

PCC/Al2O3 can be added to a room temperature solution of Example 13L in dichloromethane. After stirring overnight, the reaction mixture can be filtered and concentrated. The concentrate can be purified by flash chromatography using ethyl acetate to afford the desired product.

Workup

  1. filtrationthe reaction mixture can be filtered
  2. concentrationconcentrated
  3. concentrationThe concentrate can
  4. custombe purified by flash chromatography

Sources & evidence

ORD record
ord-17ef4c164ef64ed1ac641cd7b72bf50d
Source dataset
uspto-grants-2003_07
Patent number
US06593314B1

Reaction notes

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