Triethylamine → HCID 131723974, compound

HRID 1357508Notes

Reaction equation

HRID 1357508 reaction equation
C(N(CC)CC)C.[OH:8][C@:9]1([C:21]([O:23][CH3:24])=[O:22])[CH2:19][C@@H:18]([OH:20])[C@@H:12]2[O:13][C:14]([CH3:17])([CH3:16])[O:15][C@@H:11]2[CH2:10]1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>ClCCl>[OH:8][C@:9]1([C:21]([O:23][CH3:24])=[O:22])[CH2:19][C@@H:18]([O:20][S:26]([CH3:25])(=[O:28])=[O:27])[C@@H:12]2[O:13][C:14]([CH3:16])([CH3:17])[O:15][C@@H:11]2[CH2:10]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 11680350HCID 11680350, compound

Product 1

HCID 131723974HCID 131723974, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Triethylamine (5.0 mL, 35.9 mmol) was added dropwise to a 0° C. solution of Example 13B (4.4 g, 17.9 mmol) and methanesulfonyl chloride (1.38 mL, 17.9 mmol) in dichloromethane (60 mL). After stirring overnight, the reaction mixture was washed with saturated sodium bicarbonate, brine, dried (MgSO4), filtered and concentrated to afford the crude desired product.

Workup

  1. washthe reaction mixture was washed with saturated sodium bicarbonate, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-3cfc7cb0db6c46cbbe968a24ace31baf
Source dataset
uspto-grants-2003_07
Patent number
US06593314B1

Reaction notes

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