Potassium Carbonate → HCID 91197364, compound

HRID 1357510Notes

Reaction equation

HRID 1357510 reaction equation
C(=O)([O-])[O-].[K+].[K+].[OH:7][C@:8]1([C:21]([O:23][CH3:24])=[O:22])[CH2:13][C@@H:12]([O:14]S(C)(=O)=O)[C@H:11](O)[C@H:10]([OH:20])[CH2:9]1>CO>[OH:7][C@@:8]1([C:21]([O:23][CH3:24])=[O:22])[CH2:13][C@@H:12]([OH:14])[C@@H:11]2[C@@H:10]([O:20]2)[CH2:9]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 91107959HCID 91107959, compound

Product 1

HCID 91197364HCID 91197364, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Potassium carbonate (400 mg, 2.9 mmol) was added to a room temperature mixture of Example 17B (3.0 g, 10.56 mmol) in methanol (100 mL). After stirring for 5 hours, the reaction mixture was filtered and concentrated. The concentrate was purified by flash column chromatography using ethyl acetate to afford 1.67 g (84%) of the desired product as a colorless oil.

Workup

  1. filtrationthe reaction mixture was filtered
  2. concentrationconcentrated
  3. customThe concentrate was purified by flash column chromatography

Sources & evidence

ORD record
ord-ac4aed108b5e46f1816d501202435572
Source dataset
uspto-grants-2003_07
Patent number
US06593314B1

Reaction notes

Loading…