反应详情

温度

80 °C

Sodium (3.0 g, 130 mmol) was added to n-butanol (100 mL), and the mixture warmed to 80° C. until a solution was obtained, and then 2-chloro-nicotinic acid (10.0 g, 63.4 mmol) added, and the reaction heated under reflux for 4 hours. The cooled mixture (which solidified on cooling) was crushed and then partitioned between ethyl acetate and aqueous hydrochloric acid (sufficient to achieve pH 4), and the layers separated. The organic phase was washed with brine, and evaporated under reduced pressure. The residue was redissolved in ethyl acetate, dried (MgSO4) and re-evaporated to give the title compound as a solid (11.9 g, 96%).

1. customwas obtained
2. temperaturethe reaction heated
3. temperatureunder reflux for 4 hours
4. temperatureThe cooled mixture (which solidified on cooling)
5. customwas crushed
6. custompartitioned between ethyl acetate and aqueous hydrochloric acid (sufficient to achieve pH 4)
7. customthe layers separated
8. washThe organic phase was washed with brine
9. customevaporated under reduced pressure
10. dissolutionThe residue was redissolved in ethyl acetate
11. dry with materialdried (MgSO4)
12. customre-evaporated