Sodium hydride → HCID 18186882, compound

HRID 1357572Notes

Reaction equation

HRID 1357572 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[Cl:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[CH2:13][CH2:14][OH:15].[H-].[Na+]>>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:15][CH2:14][CH2:13][C:12]2[CH:16]=[CH:17][CH:18]=[C:10]([Cl:9])[CH:11]=2)[N:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 785042,6-DichloropyrazineHCID 78856m-Chlorophenethylic alcohol

Product 1

HCID 18186882HCID 18186882, compound

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol) and m-chlorophenethyl alcohol (515 mg, 3.30 mmol) and NaH (55% in mineral oil, 144 mg, 3.30 mmol). The crude product (0.92 g) was used directly in the next step. MS m/z 269 (M+H)+.

Sources & evidence

ORD record
ord-00824658c6a64b838d0b6095392d34d3
Source dataset
uspto-grants-2003_07
Patent number
US06593330B2

Reaction notes

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