1,2,3,4-Tetrahydro-1-naphthalenol → HCID 18186922, compound

HRID 1357573Notes

Reaction equation

HRID 1357573 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH:9]1([OH:19])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH2:10]1.[H-].[Na+]>>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:19][CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][CH2:11][CH2:10]2)[N:3]=1

Participants

4

Reactant 3

HCID 107231,2,3,4-Tetrahydro-1-naphthalenolHCID 24758Sodium hydrideHCID 785042,6-Dichloropyrazine

Product 1

HCID 18186922HCID 18186922, compound

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol) and 1,2,3,4-tetrahydro-1-naphthol (488 mg, 3.30 mmol) and NaH (55% in oil, 144 mg, 3.30 mmol). The crude product (0.86 g) was used directly in the next step. MS m/z 261 (M+H)+.

Sources & evidence

ORD record
ord-f69647a509b5435b9abb1161b7c14f0c
Source dataset
uspto-grants-2003_07
Patent number
US06593330B2

Reaction notes

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