Sodium hydride → HCID 18186914, compound

HRID 1357576Notes

Reaction equation

HRID 1357576 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][OH:17])[CH:10]=1.[H-].[Na+]>>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:17][CH2:16][CH2:15][C:11]2[CH:10]=[N:9][CH:14]=[CH:13][CH:12]=2)[N:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 785042,6-DichloropyrazineHCID 805153-Pyridineethanol

Product 1

HCID 18186914HCID 18186914, compound

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol) and 2-(3-pyridyl)ethanol (405 mg, 3.30 mmol) and NaH (55% in mineral oil, 144 mg, 3.30 mmol). The crude product, obtained as an oil (0.62 g, 88% yield), was used directly in the next step. MS m/z 235 (M)+.

Sources & evidence

ORD record
ord-dde722b270e54a138ba913fcc780d41b
Source dataset
uspto-grants-2003_07
Patent number
US06593330B2

Reaction notes

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