3,4-Dichlorobenzaldehyde → HCID 18187272, compound

HRID 1357730Notes

Reaction equation

HRID 1357730 reaction equation
[S:1]1(=[O:9])(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=O)[CH2:2]1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH:14]=O.[NH2:20][C:21]([CH3:26])=[CH:22][C:23](=[O:25])[CH3:24]>C(O)C>[Cl:10][C:11]1[CH:12]=[C:13]([CH:14]2[C:22]([C:23](=[O:25])[CH3:24])=[C:21]([CH3:26])[NH:20][C:3]3[CH2:4][CH2:5][CH2:6][S:1](=[O:9])(=[O:8])[C:2]2=3)[CH:16]=[CH:17][C:18]=1[Cl:19]

Participants

5

Reactant 3

HCID 227103,4-DichlorobenzaldehydeHCID 1368734-Amino-3-penten-2-oneHCID 11815935Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide

Product 1

HCID 18187272HCID 18187272, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of tetrahydrothiopyran-3-one-1,1-dioxide (255 mg, 1.72 mmol), 3,4-dichlorobenzaldehyde (250 mg, 1.43 mmol) and 4-amino-3-penten-2-one (140 mg, 1.41 mmol) in ethanol (5 mL) was heated to reflux for 24 hours and cooled. The solid that precipitated was collected, washed with ethanol, and dried to provide the title compound.

Workup

  1. temperatureto reflux for 24 hours
  2. temperaturecooled
  3. customThe solid that precipitated
  4. customwas collected
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-0ca31253dec54be7865a3e547425fb8a
Source dataset
uspto-grants-2003_07
Patent number
US06593335B1

Reaction notes

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