反应详情

5-Bromomethylbenzo-2,1,3-thiadiazole (4.8 g) and calcium carbonate (10 g) were heated at reflux in 1:1 dioxane/water (120 mL) for 3 hours. The solvents were evaporated and the residue was partitioned between 2N hydrochloric acid and methylene 6 3 chloride. The organic layers were dried (magnesium sulfate), evaporated and chromatographed on silica gel eluting with 1:1 ethyl acetate/hexane to provide 2.66 g of the title compound.

1. customThe solvents were evaporated
2. customthe residue was partitioned between 2N hydrochloric acid and methylene 6 3 chloride
3. dry with materialThe organic layers were dried (magnesium sulfate)
4. customevaporated
5. customchromatographed on silica gel eluting with 1:1 ethyl acetate/hexane