HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calcium Carbonate → 2,1,3-Benzothiadiazol-5-ylmethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calcium Carbonate | HCID 10112 | — |
| Reactant | 5-(Bromomethyl)-2,1,3-benzothiadiazole | HCID 591004 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 2,1,3-Benzothiadiazol-5-ylmethanol | HCID 2776294 | 76.4% |
Reaction Steps
5-Bromomethylbenzo-2,1,3-thiadiazole (4.8 g) and calcium carbonate (10 g) were heated at reflux in 1:1 dioxane/water (120 mL) for 3 hours. The solvents were evaporated and the residue was partitioned between 2N hydrochloric acid and methylene 6 3 chloride. The organic layers were dried (magnesium sulfate), evaporated and chromatographed on silica gel eluting with 1:1 ethyl acetate/hexane to provide 2.66 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06593335B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-029bc9b646b04e428b99707522c2021c |
| Source note | uspto-grants-2003_07 |