1,1'-Carbonyldiimidazole → HCID 9827440, compound

HRID 1357764Notes

Reaction equation

HRID 1357764 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][C:9]([OH:11])=O)[CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[S:24]1[C:28]2[S:29][CH2:30][C:31]3[CH:48]=[CH:47][CH:46]=[CH:45][C:32]=3[C:33](=[C:34]3[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][CH2:42][CH2:43][NH2:44])[CH2:36][CH2:35]3)[C:27]=2[CH:26]=[CH:25]1>>[S:24]1[C:28]2[S:29][CH2:30][C:31]3[CH:48]=[CH:47][CH:46]=[CH:45][C:32]=3[C:33](=[C:34]3[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][CH2:42][CH2:43][NH:44][C:9](=[O:11])[CH2:8][CH2:7][C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)[CH2:36][CH2:35]3)[C:27]=2[CH:26]=[CH:25]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 2596243-(Pyridin-3-yl)propanoic acidHCID 18187416HCID 18187416, compound

Product 1

HCID 9827440HCID 9827440, compound

Procedure

Batch size: 1.4 g (9.0 mmol) 3-(3-pyridyl)-propionic acid, 1.6 g (9.9 mmol) CDI and 4.0 g (10.8 mmol) 4-[4-(4,9-dihydro-thieno[2,3-b]-benzo[e]-thiepin-4-yliden)-piperidin-1-yl]butylamine.

Sources & evidence

ORD record
ord-9985d78b721845388518d8fba2593b6f
Source dataset
uspto-grants-2003_07
Patent number
US06593344B1

Reaction notes

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