Hydrazine hydrate (1:1) → HCID 11149025, compound

HRID 1357839Notes

Reaction equation

HRID 1357839 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=O)[CH2:7][C:8](=O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].O.[NH2:18][NH2:19]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[NH:19][N:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11184018HCID 11184018, compound

Product 1

HCID 11149025HCID 11149025, compoundYield 59.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (20 ml), 1-(2-thienyl)-1,3-nonanedione (1.30 g) and hydrazine hydrate (1.26 g) are refluxed for 3 hours by heating. After the reaction is completed, the solvent is distilled off. The obtained residue is added to petroleum ether and crystallized to obtain the objective 3-(2-thienyl)-5-n-hexylpyrazole (0.76 g) as colorless crystals. mp. 53-55° C.

Workup

  1. temperatureby heating
  2. distillationthe solvent is distilled off
  3. additionThe obtained residue is added to petroleum ether
  4. customcrystallized

Sources & evidence

ORD record
ord-4697ef2ff50c4fcb866d05523d523fa2
Source dataset
uspto-grants-2003_07
Patent number
US06593358B1

Reaction notes

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