反应详情

温度

50 °C

A solution of ethyl (R) 3-{4-[2-(4-methyl-2-o-tolylaminobenzoxazol-6-yl)acetylamino]phenyl}butanoate [0.14 g, Reference Example 15(a)] in methanol (2 mL) was treated with aqueous sodium hydroxide solution (1.2 mL, 1M) and then stirred at 50° C. for 2 hours. The mixture was diluted with water and partially evaporated. The residue was washed with diethyl ether and then acidified to pH 4. The precipitated solid was filtered and sucked dry to give the title compound (0.07 g) as a tan solid. LC-MS: RT=3.38 minutes (100% by ELSD); MS (ES+), 458 (MH+).

1. custompartially evaporated
2. washThe residue was washed with diethyl ether
3. filtrationThe precipitated solid was filtered
4. customsucked dry