Sodium Hydroxide → HCID 18188099, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl (R) 3-{4-[2-(4-methyl-2-o-tolylaminobenzoxazol-6-yl)acetylamino]phenyl}butanoate [0.14 g, Reference Example 15(a)] in methanol (2 mL) was treated with aqueous sodium hydroxide solution (1.2 mL, 1M) and then stirred at 50° C. for 2 hours. The mixture was diluted with water and partially evaporated. The residue was washed with diethyl ether and then acidified to pH 4. The precipitated solid was filtered and sucked dry to give the title compound (0.07 g) as a tan solid. LC-MS: RT=3.38 minutes (100% by ELSD); MS (ES+), 458 (MH+).

Provenance & Evidence