反应详情

温度

50 °C

A solution of ethyl 3(R)-(4-nitrophenyl)butanoate (4.0 g, Reference Example 2) in ethanol (100 mL) was treated with ammonium formate (about 15 g). The reaction mixture was immersed in an oil-bath in a single neck flask, the solution was heated to 50° C., then treated with palladium on charcoal (about 1 g, 5%) to give an immediate visible effervescence. The mixture was kept at 50° C. with stirring for about an hour, then filtered through filter-aid. The filtrate was evaporated and the residue was partitioned between tert-butyl methyl ether and water. The organic phase was dried then evaporated to give the title compound (2.8 g) as a light brown gum.

1. customThe reaction mixture was immersed in an oil-bath in a single neck flask
2. customto give an immediate visible effervescence
3. customwas kept at 50° C.
4. filtrationfiltered
5. filtrationthrough filter-aid
6. customThe filtrate was evaporated
7. customthe residue was partitioned between tert-butyl methyl ether and water
8. customThe organic phase was dried
9. customthen evaporated