反应详情

温度

145 °C

A stirred mixture of 3,5-dimethoxy-4-nitrophenylacetic acid (0.4 g, Reference Example 13) and pyridine hydrochloride (6 g) was heated at 145° C., under argon, for 4 hours. The cooled reaction mixture was partitioned between ethyl acetate and water. The organic phase was washed with water, then with brine, then dried and then evaporated to give a 1:1 mixture of the title compound and starting material (0.37 g) which was used without further purification.

1. customThe cooled reaction mixture
2. customwas partitioned between ethyl acetate and water
3. washThe organic phase was washed with water
4. dry with materialwith brine, then dried
5. customevaporated
6. customto give