Pyridinium chloride → 3-Hydroxy-5-methoxy4-nitrophenylacetic acid

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 3,5-dimethoxy-4-nitrophenylacetic acid (0.4 g, Reference Example 13) and pyridine hydrochloride (6 g) was heated at 145° C., under argon, for 4 hours. The cooled reaction mixture was partitioned between ethyl acetate and water. The organic phase was washed with water, then with brine, then dried and then evaporated to give a 1:1 mixture of the title compound and starting material (0.37 g) which was used without further purification.

Provenance & Evidence