Trifluoroacetic acid → HCID 131723146, compound

HRID 1357901Notes

Reaction equation

HRID 1357901 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][CH2:15][CH2:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18187525HCID 18187525, compound

Product 1

HCID 131723146HCID 131723146, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-(t-butoxycarbonyl)-4-(3-(2-pyridyl)propyl)piperidine (from Step A) (128 mg, 0.42 mmol) in methylene chloride (1 mL) was added TFA (1 mL). After stirring for 2 h at rt, the reaction was concentrated to give the title compound (36 mg).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-4b0349c0b35b46f09a46e073b43f3f03
Source dataset
uspto-grants-2003_07
Patent number
US06593346B2

Reaction notes

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