Acetic Acid → 4-(2-Hvdroxyeth-1-yl)piperidine Acetic Acid Salt

HRID 1357918Notes

Reaction equation

HRID 1357918 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1.[H][H].[C:12]([OH:15])(=[O:14])[CH3:13]>[Pt]=O>[C:12]([OH:15])(=[O:14])[CH3:13].[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 729214-PyridineethanolHCID 178418361HCID 178418361, compound

Product 1

HCID 181878314-(2-Hvdroxyeth-1-yl)piperidine Acetic Acid SaltYield 100%

Reagents, catalysts & solvents 1

HCID 82844Platinum oxide (PtO)Catalyst

Procedure

Combined 4-(2-hydroxyeth-1-yl)pyridine (25 g, 0.2 mol) and platinum oxide (1 g, 4.4 mmol) in 400 mL acetic acid. Placed under 45 psi hydrogen at 60° C. for 24 h. Decanted, then filtered through Celite and removed the solvent to afford 38 g (100%) of the crude product, which was used without further purification.

Workup

  1. customDecanted
  2. filtrationfiltered through Celite
  3. customremoved the solvent

Sources & evidence

ORD record
ord-8ab9c854191949a9877cf8e7d514c978
Source dataset
uspto-grants-2003_07
Patent number
US06593346B2

Reaction notes

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