Trifluoroacetic acid → HCID 131723147, compound

HRID 1357924Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([CH2:9][N:10]2[CH:14]=[C:13]([CH:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[C:12]([CH2:28][CH3:29])=[N:11]2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:32]([OH:38])([C:34]([F:37])([F:36])[F:35])=[O:33]>>[OH:38][C:32]([C:34]([F:37])([F:36])[F:35])=[O:33].[OH:38][C:32]([C:34]([F:37])([F:36])[F:35])=[O:33].[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:9][N:10]2[CH:14]=[C:13]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([CH2:28][CH3:29])=[N:11]2)=[CH:30][CH:31]=1)(=[O:3])=[O:4]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 18187477HCID 18187477, compound

Product 1

HCID 131723147HCID 131723147, compound

Procedure

4-((1-(4-Methylsulfonylbenzyl)-3-ethyl)-(1H)-pyrazol-4-yl)-N-t-butoxylcarbonylpiperidine from Step C was treated with TFA for 1 h and evaporated to afford the title compound as the TFA salt.

Workup

customevaporated

Sources & evidence

ORD record: ord-54fe4a91cb9348c3abcb05cb2ff83d91
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06593346B2

Reaction notes

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