Hydrochloric Acid → HCID 131723149, compound

HRID 1357953Notes

Reaction equation

HRID 1357953 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, compound

Product 1

HCID 131723149HCID 131723149, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

Workup

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-59e19765ea0c45c0805cffacbbc01c4c
Source dataset
uspto-grants-2003_07
Patent number
US06593346B2

Reaction notes

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